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Now, Gilead's latest HCV drug, Epclusa, is enjoying tremendous success. However, Gilead's HCV success came at a cost. Its drugs cured so many patients that newer patients are harder to find than they were a couple of years ago. Gilead also faces more competition now. This has resulted in the big biotech's stock nosediving around 20% over the last 12 months. There's still a solid investment case for Gilead Sciences, though. The biotech's pipeline includes 10 late-stage programs and 15 mid-stage programs. Gilead is looking to continue its dominance in the HIV market while also expanding into new indications. Of particular note is the biotech's focus on non-alcoholic steatohepatitis (NASH). Gilead has three experimental drugs targeting treatment of NASH, a disease that has been dubbed the "next hepatitis C" by some because of its market potential. Gilead also is setting its sights on expanding its oncology portfolio.

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